Working Principle and Application of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

Rapid Mixer Granulator RMG (High Shear Mixer): The Complete Guide

Introduction

Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator is a very important pharmaceutical equipment used in the process of fast wet mixing, homogenization, humidification and powder granulating. Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator plays an important role in granulation line of solid dosage forms.



Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator connects with downstream equipment fluid bed dryer form closed granulation.
However, despite the numerous importance of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator , a lot of people are quite unfamiliar with this equipment.
Thus, at Senieer, we have written this comprehensive guide to provide an answer to any questions you may want to ask about Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator . We believe you will find this ultimate guide to Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator very useful to you.
You can see our Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator in action here
Whether you are looking for a high shear mixer for sale or you need the best homogenizer mixer for your pharmaceutical wet granulation process, you will find all the necessary information in this ultimate guide.
Some of the topics we have covered in this ultimate guide to Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator include:

• Popular Manufacturers of High Shear Mixer
• Types of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator
• Granulation Method and Process Monitoring
• Wet Granulation Process
• Advantages and Disadvantages of powder mixer machine
• How to choose the best Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator
• Methods of Shipping High Shear Mixer to America, Europe, Canada, and other countries
• Frequently Asked Questions on High Shear Mixer

Chapter 1: Description of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

Are you interested in buying Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator , but you have never been changed to see the homogenizing machine?
Here we present to you the description of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator .
However, before we dive into that, let's quickly check the definition of granulation.

What is granulation?

Granulation involves the process of gathering particles together through the creation of bonds between them.
In generating bonds during the granulating process, binding agents or compression are used.

What does a Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator do?

Also called homogenizer or mixing machine, Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator is pharmaceutical equipment that transports or disperses a section or ingredient which can be solid, liquid or gas. The ingredient is transported into a primary continuous liquid section that is usually incompatible.

Parts of a Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator and their functions

Senieer Shear Mixer mainly contains loading system, impeller system, spray system, chopper system, cone mill (as an optional item) system, control system, etc.

A rotor or vein along with the stationary mechanical device. Also, the fixed part can be an associate array of stators and rotors. The device is engaged with a tank containing the ingredients to be mixed.
A pipe is passed for the passage of the ingredients to form a Shear. The Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator produces granular products which can be used in a pharmaceutical company.
Other types of the high Shear mixer can generate suspensions (gas distributed in liquid) as well as emulsions. The result of the granulation process can also be employed in other industries besides pharmaceutical.
Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator also widely used in health product, food, cosmetic, chemical, the cosmetics industry and adhesives derived from homogenization, emulsification, particle size reduction, and dispersions.
In high Shear mixer granulation process, the solid part of the mixture is required. Fluids or solutions are used to serve as an associate that aids the process.
After the solid part has been formed, it is chopped down to the needed particle size which is subsequently passed to the drying bed.
From the drying bed, the fluid is completely removed to form granulated products.

Features of mixing machine or Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

The equipment is beautifully designed to appeal to the eye. There are various product types and designs from different manufacturers of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator .
However, all the designs on Senieer follow Current Good Manufacturing Practices compliance (cGMP) and the US FDA.
Also, our Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator carries out the automated mixing and granulating process using a single bowl.
Another superior feature of Senieer highs shear mixer granulator is the extremely high precision mixing and Short Batch Time for granulation coupled with easy to clean and residue-free discharge of granules, vacuum conveying material (as an optional item) is available on your request.

We also have exclusive design spotting a three mixing impeller and also blade angle used in forceful pushing out products.
For cutting lumps and turning out granules, our high Shear mixer has sturdily built chopper blade that seamlessly takes care of the process.
The Senieer mixer also features dual speed mixing impeller and an intensive chopper for mixing and granulating respectively.
Electro-pneumatically operated flush fitting discharge plug and air pursing seal for the two shafts that come with it.
Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator is easily controlled, thanks to the PLC and the huge HMI touch screen.

It also has an advanced heating and cooling mechanism with the product bowl jacketing (as an optional item), the heating media according to your requirements (water or oil) and the vacuum-like process of mixing.
The impeller and chopper rocks variable speed drive.
You can charge the material by vacuum or by manual.


You can add binder by spraying the system with a peristaltic pump a peristaltic pump, pneumatic diaphragm pump, and pressure tank, it is according your process and capacity requirements, gear while there is the flameproof electric motor in place.

Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator Safety Features

With High Senieer Shear Mixer Granulator, you can be sure of optimum safety with the adequate features in place.
Open bowl cover state, impeller and chopper can’t work, there is logical protection.
It has an enclosed total drive transmission system with a limit switch top lid installed to guide against the accidental opening of caps during operation. Automatic
Also, the pressure switch is installed so that you can ensure optimum pressure in the equipment.
There is an emergency stop button and overload relay protection to prevent accidents during use.
Also, explosion-proof system (as an optional item) is available on your request. Explosion-proof design includes explosion-proof touch screen, explosion-proof junction box, explosion-proof winding tube, explosion-proof motor.
Production Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator parts: WIPs system is an optional item of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator ; it can share one set of WIP system with fluid bed equipment.

Chapter 2: Types of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

If you are looking for the various types of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s that exist, you may find it difficult to select which one to choose.
However, as your partner in guiding you through the process of selecting the best high shear homogenizer, Senieer has provided some of the factors you have to consider in selecting the best type of mixing equipment for your industrial or pharmaceutical needs.

The dosing system types

Ensure to check the dosing system type that is in place in your granulator machine. Is it manual or automatic system? Does it include binding solution or powder dosing system? Whichever works for you is what you should go for. Nevertheless, you have to put in mind the purpose of purchasing the mixer machine in the first place.

The impeller blade design

The granulation process efficiency is determined by the design that the impeller blade carries. A typical homogenizer mixer primarily has different numbers of blades which can be up to three in some granulator machine. Another factor you need to put into mind is the design and the position of the impeller blade as they are of equally great significance.


Usually, in Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator , the position of the impeller tip is lateral to facilitate to reduce the probability of dead spots. The function of the impeller is to mix and form granules.
Also, the rotation speed of the homogenized mixer depends on the specification of the machine including the design.

Position of the impeller

Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s are classified based on the usage; there is laboratory style of high shear mixer and the production style.
Laboratory style Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s are primarily used in the homogenization of the ingredients used in making different drugs and granules in the pharmaceutical industry.

Production style Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s on the other hand are used in the manufacturing industries. Mixing of ingredients used in making granules.
Senieer has Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s that are effective as mixer machines in both laboratory and industrial uses.

Chapter 3: How Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator Works

Are you interested in how high shear mixer works? The technology behind high shear mixer is really complex and fascinating.
Regardless of the brand you are choosing, high shear homogenizers follow similar approach om carrying out their granulation operation.
The working principle of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator basically follow the following processes;

Mixing of the powder

The high shear granulation process starts with the mixing of the powder in a bowl using the impeller.

Addition of binder or granulation liquid

Next, the impeller proceeds to mix and spread the granulation liquid also known as binder at a speed between 5rpm – 300rpm
Dampening or wetting of powder
The Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator ’s part, the chopper breaks the wet lump to generate granules at a speed of 200 -3000rpm.

Nucleation process (formation of crystals powder)

At this stage, you will notice the formation of crystal powder otherwise called nucleation process.

Granule growth and densification of powder

Agglomeration of granule or the power densification occurs next through the incorporation of granulation fluid into the powder using high-power-per-unit mass. This process is achieved through the rotation of the high shear forces.

Breakage and attrition of granule

The granulation process ends with the breakage and attrition of granules which is then transferred to wherever it is needed whether for pharmaceutical purposes or other industrial uses.

Chapter 4: High Shear Mixer Wet Granulation Process Guide

We will be looking at the wet granulation process. You can rest assured that this chapter will answer all the questions you have concerning the wet granulation process of high shear mixer. We will be checking some of the questions you may have such as: What are the problems you can encounter while using Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator ? How can you balance a successful test on laboratory high shear granulator and a production failure in high shear granulation machine? What are the difficulties that you can encounter during lab wet granulation process amplification? This chapter covers areas such as the wet granulation equipment, and how you can master the wet granulation process as a user or an operator of pharmaceutical equipment. Several factors can affect the wet granulation process particularly connectivity during amplification.

What you should know about the wet granulation process

Firstly, it is important to note that the wet granulation process mostly occurs in solid dosage forms.
Senieer, the leading supplier of the high shear mixer in China ensures the scalability from R&D high shear mixer supplying to putting level Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator for sale.

Parts of a Laboratory high shear mixer

You may be interested in knowing the parts that make laboratory high shear functional. We have highlighted some of the crucial parts, they include;

Senieer GLS Laboratory High Shear Mixer

• Impeller: the impeller is unique and highly functional
• Chopper: it comes in compact assembly, and the arrangement is very easy to remove
• Direct drive system: this enhances the productivity of the Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator
• Interchangeable bowl: this is available on request, and has a changeover time of 5 -7 minutes. After the changeover time, the mixing equipment will be available to carry out the processing
• Electric and pneumatic panel: features easy-to-access panels that guarantee safety during the wet granulation process.
• 

https://www.researchgate.net/publication/275518904_Improved_Tablet_Production_by_Modified_Granulation_Techniques-A_Review/figures?lo=1&utm_source=google&utm_medium=organic
Senieer is always at the forefront of partnering with trusted manufacturers of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator for innovative designs that enhance solid dosage production. This helps in achieving top-notch pharmaceutical manufacturing operations. We can also test for your process to make a custom design for your Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator .
Raw materials are converted into final dosage forms in development, pilot, clinical and production volumes using wet granulation in one continuous granulation line.

Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator also named high shear mixer, homogenized mixer or rapid mixer granulator offers the outstanding advantages of efficiency and product uniformity achieved with High Shear Mixers.
Senieer shear mixer granulators include GL Series lab high shear mixer, GLS high shear granulation, and GM Series rapid mixer Granulators.

Model		GL-100	GL-200	GL-300	GL-400	GL-500	GL-600	GL- 800
Hopper volume(L)		100	200	300	400	500	600	800
Effective volume(L)		40-80	80-160	120-240	160-320	200-400	240-480	320-640
Feeding volume(kg)		20-40	40-80	60-120	80-160	100-200	120-240	160-320
Mixing rotation speed(rpm)		28-280	22-220	20-200	18-152	17-169	15-155	15-158
Cutting rotation speed(rpm)		300-2900	300-2900	300-2900	300-2900	300-2900	300-2900	300-2900
Mixing power(kw)		11	18.5	22	30	37	45	55
Cutting power(kw)		4	4	5.5	5.5	7.5	11	15
Compressed air	（Mpa) Pressure	0.4-0.6	0.4-0.6	0.4-0.6	0.4-0.6	0.4-0.6	0.4-0.6	0.4-0.6
	(M3/min) Consumption	0.2-0.8	0.2-0.8	0.2-0.8	0.2-1.1	0.2-1.1	0.2-1.5	0.2-1.5

Model		GM-100	GM-200	GM-300	GM-400	GM-500	GM-600	GM-800
Hopper volume(L)		100	200	300	400	500	600	800
Effective volume(L)		40-80	80-160	120-240	160-320	200-400	240-480	320-640
Feeding volume(kg)		20-40	40-80	60-120	80-160	100-200	120-240	160-320
Mixing rotation speed(rpm)		28-280	22-220	20-200	18-152	17-169	15-155	15-158
Cutting rotation speed(rpm)		300-2900	300-2900	300-2900	300-2900	300-2900	300-2900	300-2900
Mill rotation speed(rpm)		200-900	200-900	200-900	200-900	200-900	200-900	200-900
Mixing power(kw)		11	18.5	22	30	37	45	55
Cutting power(kw)		4	4	5.5	5.5	7.5	11	15
Mill power(kw)		2.2	2.2	2.2	2.2	3	3	3
Compressed air	Pressure(Mpa)	0.4-0.6	0.4-0.6	0.4-0.6	0.4 - 0.6	0.4-0.6	0.4-0.6	0.4-0.6
	Consumption(M3/min)	0.2-0.8	0.2-0.8	0.2-0.8	0.2-1.1	0.2-1.1	0.2-1.5	0.2-1.5

The rapid granulator mixer whole set consists of a loading system, impeller system, spray system, chopper system, wet cone mill system(as an optional itme), control system, etc.


Senieer high shear mixers’ chopper ensures an optimum granular structure, the GM series Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator equipped with a chopper and high straight shear mixing blades.
The position of the chopper in the lower third of the working vessel results in its very high level of efficiency, even where there are minimum filling volumes.
Senieer shear mixer granulator rapid mixer’s chopper exists in two speed or variable speed.
Main shaft and chopper shaft are designed with one-way flow air seal, flow rate, the pressure of air seal can be measured & controlled to prevent and detect powder or water from entering inside.
Senieer super mixer auto controls stop position of the impeller; auto elevates the main shaft pneumatically for the visible check without dismantling.
The all-important tool in the wet granulation is the bottom driven Z-Rotor. The unique geometry of the Z-Rotor ensures maximum efficiency while minimizing the power required.
Cutting-edge measuring and manufacturing processes ensure that the gap between the rotor and the bottom of the working bowl is kept to a minimum while maximizing product yield.
Senieer Unique technology guarantees ease of handling.
Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator rapid have good quality with affordable prices in China.
If you want to start the wet granulation equipment business, please contact us for more details, we will send you all quotations for machines, and drawing.
We can customize all your equipment based on your requirements. Once you approve the detailed user requirement statement (URS), we can supply the Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator drawing and suggestion for your factory layout.
Also, we provide our technical support, custom design for your process and layout.
Whether it is from laboratory Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator equipment or amplifying batch high shear mixer equipment, it is generally known that it is difficult to design and amplify.
This is because are many process parameters and competing mechanisms in the wet granulator.
Also, the production batch Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator equipment and existing production high shear mixer equipment to larger production Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator equipment design is demanding too.

Why difficult from R&D high shear mixer to amplifying batch Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator ?

High-shear wet granulation is the granulation of fine powder by a liquid binder. When the binder is added to the granulating bowl, the impeller and the chopper of the wet granulator begin to shear to form a specific property — particles, including particle size, particle strength, dissolution, compressibility, and content uniformity.
To achieve the desired particle properties, several granulation parameters need to be optimized, including the size and geometry of the granulator, the speed of the impeller, the speed of the chopper, the mode of addition of the binder, the flow rate, and the granulation time.
The traditional wet granulation process is a method of gradual enlargement and problem finding.
Changing the parameters of the granulator affects the properties of the granule in a variety of ways.
Without understanding the principle of amplification, you will encounter changes in all variables.
The process of particle formation involves three stages: nucleation growth, and growth of the mother nucleus, and rupture.
Nucleation is considered to be the beginning of granulation, including the formation of the fundamental particles, also known as the mother nucleus.
In high shear wet granulation, the mother nucleus is formed at the stage where the liquid is in contact with the powder bed and the internal reaction of the powder particles.
The growth of the mother nucleus is due to the adhesion of the powder particles to the surface of the mother nucleus or the combination of two or more particles. This step usually also makes the particles denser.
When the force in the granulating bowl (shear force, force from the impeller, chopper or granulation wall) exceeds the particle strength, the particles are broken.
Changing the above parameters may change the yield and properties of the particles. Some suggestions and comments on how to control granulation parameters will be given below.

How to control granulation parameters? 

Granulator geometry

Many companies do not control the geometry of the high shear mixer, but the laboratory Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator equipment is preferably selected or designed to be similar to the device with the same geometry, i.e., the same aspect ratio.
Amplification between devices with similar geometric structures is equivalent to amplifying only the stirring impeller speed, which is much simpler. It is also essential to amplify the speed of the impeller.
The effect of the stirring impeller rotation speed on the particle size is primarily related to the composition characteristics of the formulation and the granulation mechanism of the process.
In some cases, increasing the speed of the impeller can increase the particle size. In some cases, increasing the speed of the impeller increases the breakage rate of the particles, resulting in a decrease in particles.
The most important thing is to consider the air intake assembly of the high shear mixer.

During the operation of many granulators, the internal particles appear twisted rope, and the powder bed moves in a circular shape in the granulating pot under the action of the air system.
If the stirring impeller rotation speed is too low, the inside of the granulating bowl will be in a bumping state, so that the surface movement of the powder bed layer is relatively slow, and only the bumping state caused by the stirring impeller rotation speed is obtained.
The twisted rope state is vital for the mixing of the powder in the granulating pot and the distribution of the liquid, and mainly affects the size of the mother nucleus. There have been some laws for the amplification of the stirring impeller speed. Some people advocate a constant linear velocity.
Some people suggest that the Froude number (the ratio of centrifugal force to gravity inside the high shear mixer) is constant. Others have suggested using a continuous shear force inside the granulator, and they recommend using the following formula when zooming in NDn Where N is the angular velocity of the impeller, D is the diameter of the paddle, and n is a constant (n is found to be equal to 0.85, although this value is likely to be prescription-system dependent)

·      Chopper speed

The role of the Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator chopper is not very clear. Based on the nature of most of the mixtures, we found that it neither promotes the growth of the mass, increases the compactness of the mass, or breaks the particles.
Increasing the size of the shear mixer granulator can reduce the frequency of interaction between the granules and the chopper. In this case, it is an excellent idea to fix the linear speed of the cutting blade during the enlargement process because the particles are similarly impacted.
However, if other variables in the amplification process cause the particles to increase, increasing the chopper speed can reduce the size of the particles.
How to add the binder and the flow rate
Some advanced particle research has been devoted to the development of a mother core state diagram that describes the nucleation process under a given granulation process. This map has two dimensionless parameters: the time the droplet enters the powder bed and the jet flow rate (which can be considered as the ratio of the liquid spray rate to the tumbling speed of the bed surface particles).
The droplets enter the powder bed for a short period (i.e., droplets that quickly enter the powder bed) and low jet flow (i.e., the droplets can be sprayed well onto the powder surface), and their nucleation behavior is controlled by droplets. That is to say, many mother cores are formed by a single droplet, and the size range of the mother core is relatively narrow. Either the time of droplets entering the bed increases or the increase of the spray flow rate leads to over-wetting.
The liquid deposits on the surface of the powder bed to form a large mother nucleus. In this case, mechanical force is required to destroy it. Force destruction leads to a wide distribution of the size of the mother nucleus. The size distribution of the nucleus is the beginning of granulation. For many prescriptions, it is critical to forming a similar size nucleus through the granulator. If the amplification process is to achieve the state in which the mother core is controlled by the droplets, it is required that the droplet size during the amplification process is the same as the droplet size during the small test (the time when the droplet enters the powder bed is similar).
Also, the low discharge flow rate is necessary (formation of a single sheet) for the droplet mother core to be effective. The method of reducing the spray flow rate is to ensure that the spray width covers the effective surface of the bed (i.e., the radius of the granulator). This is to reduce the volume flow rate of the adhesive and increase the tumbling speed of the powder during the process of wet granulation in high shear mixer.
Granulation time: It is difficult to determine the effect of the granulation time on the properties of the granules by different granulators.  The mechanical distribution of the liquid binder in a sizeable granulating pot requires enormous time. However, this is primarily related to the formulation and process parameters.
The following formula can amplify granulation time: Tx/ty=(Sx/Sy)(Vx/Vy) Wherein, x is the granulating bowl before enlargement, y is the enlarged granulating pot, tx, ty is the granulation time, Sx, S y is the inner surface area of ​​the granulating pot, and Vx, Vy is the granulating pot volume.
Anyway, there are so many factors control parameters, beyond what we have written above.
That is why you should review the technology behind D&R high shear mixer and manufacturing high shear mixer to know more about the high shear mixer.
Through theory and technical parameter specifications, I believe you have learned a lot about the high shear mixer, especially the reason for the difficulty in R&D high shear mixer to amplifying batch Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator .
Senieer focus on research about technology, special combines machinery, and process which are key components from importation to production.
Thus, Senieer as a global high shear mixer rapid granulator mixer manufacturer and supplier is well versed on the sales and supply of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator .
At Senieer, we are commited to providing you quality products as we are concerned about building our brand.
As such, we appreciate the feedback from you, not only in the aspect of reviews on machinery you purchase from us alone, but also our entire work process. They help us improve in all phases of our operation; from customer service to aftersales maintenance.

Chapter 5: Factors affecting the granulation process and Advantages of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

There are many factors that can affect the granulation process of high shear mixer. If you are not quite familiar with how this homogenizer mixer works, you can find it difficult to know how to best make use of it.
We have highlighted some of the factors you have to pay attention to if you want to maximize the productivity of your high mixer machine. They include;

• • • Formulation variables

The type and amount of binders used as an inactive material during the granulation process will go a long way in affecting the entire granulation process.

• • • Physical Properties of Ingredients

The physical properties of the materials to be granulated can play a huge role in affecting the granulation process. Physical properties such as size, hardness and the nature of the materials should be considered.

• • • Binder Materials

There are several binder materials and solutions that you can use. Some of the popular excipients or binder materials used for Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator include, starch paste, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polypropylene pyrrolidone, etc.
Natural Binders: cellulose, acacia, gelatine, starch paste, alginic acid, tragacanth, and pregelatinized starch
Sugars: Liquid glucose, sucrose
Synthetic and Semisynthetic Polymers: Ethyl Cellulose, Hydroxy Propyl Cellulose, Hydroxy Propyl Methyl Cellulose (HPMC), Methyl Cellulose, Polyvinyl Alcohols, Polyethylene Glycol (PEG), and Polyvinyl Pyrrolidone (PVP).

• • • Process variables

These include all the variables that can affect the outcome of the granulation process. Listed below are some of these process variables;

1. Chopper speed
2. Designs of Granulator

• • • Methods of adding granulating solution

1. Rate of granulating solution
2. Speed of Impeller
3. Granulator bowl load

• • • Wet-massing tire

Advantages of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s

Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator has several advantages of mixing equipment with low shear. Some of the benefits include;

• Granulation of highly cohesive materials which contain hydrophilic polymers. Such granulation cannot be derived from low shear
• In high shear granulation, the entire granulation process require shorter time compared to low shear
• Only a handful of binder is needed which helps to keep the cost of production at a minimal level.
• There is lesser exposure of workers to dust with high shear granulation, thanks to reduced dust generation in high shear granulation process
• You can predict the outcome of granulation process when you use high shear mixer
• It is easy to achieve a uniform particle size distribution with high shear, and also reproducible less friable granules
• You can achieve drying in shorter time with Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

Chapter 6: How to choose the best Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

Like every other equipment and machinery, selecting the perfect Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator for your company can be a lot challenging.
Often, you will encounter a lot of advertisement and several companies boasting how their high shear mixer is the next best invention after sliced bread.
However, it is very easy to make a bogus claim. It’s left to you as a buyer to shift the shaft from the seed.
At Senieer, we have helped you with what to look for before you spend your hard-earned money on mixing equipment that doesn’t offer you the actual value for money.
Read on as we expertly dissect the factors to consider.

·      Check the Brand Reputation

Whether your business is located in United States, South Korea, Thailand, Germany, Columbia, Egypt, Indonesia, Malaysia, Pakistan, Bangladesh, Russia or Vietnam and you need quality high shear mixer for sale in China, the first thing you should check is the reputation of the brand you are dealing with.
Are they reliable, flexible with reputable durability? Do they offer aftersales services? Is their warranty on their products and who can vouch for their integrity?
The reputation of high shear mixer manufacturer a partnered with can go a long way in determining how reliable their product will be.
Some companies may claim they are the best and even appear the highest in organic search, thanks to SEO. However, that is not enough as an indication. Ask for recommendations from people that have had a deal with them in time past.
Online reviews can be manipulated, thus, ensure that you do your research very well so that you don’t end up buying overpriced inferior products.

·      Go for Flexibility

Just like multitasking is a highly valuable skill in recruiting employees, so is flexibility in choosing a mixer machine.
You surely want a product that can be used across many fields such as pharmaceutical to food, cosmetics and other industrial application of high shear technology.
Also, you should put into consideration factors such as recipes, volume, and products — the better, the higher the level of flexibility, the better for your company.
Some of the features to consider in terms of flexibility include:

• Scalability – turning out of consistently quality output irrespective of the volume of the production.
• PLC Control – The whole process control by Programmable Logic Controller. The control system is a Siemens S7-300 smart series stored program control (PLC). It features an operator panel unit of 12 inch Siemens HMI panel available on your request (as an optional item).
• 

To prevent sticking of materials especially under anchor/impeller are,
Service (adjustment) should be provided by one operator.
You can also control the following; Loading-Mixing time, impeller speed, chopper speed, solution feeding speed, solution feeding period, granulation period, discharging control.
There are three levels passwords to access the panel.
The interlocks and alarms are designed in the control sys and HMI showing-able. The specific page on HMI recording the historic alarms is designed.
It can be frustrating when you use mixing equipment that gives no room for prediction and control.
Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator that allows you to predict and control the parameters such as the size of binder droplet and distribution of particles is best for you, and that exactly what we offer at Senieer.
Versatility – Is your company often producing different varieties of products? If yes, then you should try to go for granulation equipment that offers versatility. A mixing equipment that will turn out the specific product that you need; whether it is western medicine granules, tablet granules, capsule filling granules for pharmaceutical or chemical industries. It is suitable for less sticky granules.·
Differing Volume – sometimes you may want to produce in batches, semi-continuous or continuous production. You should focus on Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator that ensures a seamless switch in variable volumes. This will particularly help in a situation where there is a higher demand in output without the capital to invest in new mixing equipment.

·      Pay attention to details

In the industries where every ounce of input counts, having the homogenized mixer that gives you the perfect output is essential. In pharmaceutical mixing, you as a manufacturer of the drug should focus on how to maximize your production better and cut the cost of production as much as possible. Select a high shear mixer that allows you to save time without compromising the quality of products. Also, having a product that lowers the energy consumed is good as well the one that optimizes how you use the ingredients.

·      Put safety first

Your preferred high shear mixer must offer the maximum protection to both operators and the output as well.

• • • Operator Safety

As we are all aware that mechanical equipment is susceptible to faults that are liable to cause an accident, the Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator you are buying must prioritize the safety of users. It must show a specific interest in the protection of users in case of a hazard. Such a homogenized mixer must be easy to control for safety measures.

• • • Output Safety

Most mixing equipment will be used in the manufacturing of food and drug. As such, a very high level of safety is required. You should steer clear of any products that can tarnish your business image and brand reputation. Here are some of the factors you should look out for in your choice of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator ;

• Effective WIP system (as an optional item)
• 

• Proven and trackable record on safety
• FDA and EFSA certified as equipment for food-related materials
• Compliance from components supplier regular audit
• Hygienically designed mixer and possibly EHEDG approved

·      Select the most cost-effective

The price of a product is a significant determinant in the choice of product to make. However, if care is not taken, the price can be highly misleading. This is because sometimes the most expensive product is not the best while the cheapest may not necessarily be the most inferior. The key to choosing the best mixer machine is to go for the one that gives you the best value for money. The output, durability, flexibility and all other factors highlighted above can help you in making a decision.
You can check this video to see what one of our clients has to say about us
https://www.youtube.com/watch?v=PA9wO4ALVp4

Chapter 7: Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator  

Now that you have identified all the factors to consider in choosing the right Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator , another question to ask is, which supplier should you choose particularly when buying mixing equipment from China.
There are many suppliers of mixer machine in China. However, Senieer edges them all.
Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s are reputed to be highly effective and get the job done in the lowest amount of time possible.
Senieer homogenizer mixers are fast, safe and efficient in turning out fine particles of different sizes.
If you are a manufacturer of drug, cosmetics, food, health products, chemical or other productions that require the use of a mixing machine, then Senieer meets your needs succinctly.
All Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator has a perfect degree of homogenization which makes it suitable across all sectors such as pharmaceutical, health products, beauty products, and food.
Senieer products are known to be precise and produce an unusually high rate of shears that homogenizes products to derive the desired level of output uniformity.
In partnership with the trusted brands in China and across the globe, Senieer offers cutting edge and sophisticated granulation technology in supplying quality and durable products to manufactures and importers alike.
Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator is specifically built to enhance efficiency and lower the cost of operation which in turn save you time and money.
If you are looking for a high shear mixer for sale that allows you to achieve a turnout of highly homogenized and uniform particle size or granule, then you have no better alternative than Senieer high shear mixer.
You can anticipate a faster and consistent output in an uncharacteristically single pass compared to the others which take more time.
As a customer, you can be confident that Senieer products tick all the boxes when it comes to the factors to consider in choosing the right Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator .

Why you should choose Senieer as your number one supplier of Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

Regardless of the information at your disposal, you will find it challenging to select a particular Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator manufacturer that gives you the best value for money.
Senieer as a market leader is one of the most reputable high shear manufacturer and supplier in China. Highly-rated as one-stop smart pharmaceutical production expert with over 30 years’ of supplying pharmaceutical and industrial products such as High Shear Mixer, Fluid Bed Dryer, Fluid Bed Processor, Fluid Bed Granulator, Lifting column products, Cone Mill, Vacuum Conveying, Bin Blender, Coating machine, Clean Room System and many more.
Also, Senieer offers expert solution to all pharmaceutical mixing equipment issues for individuals and organizations.
If you are looking for high shear mixer for sale or you are in need of reliable tested and trusted supplier of pharmaceutical equipment especially high shear and other mixing machines, Senieer is a name you can count on.
These are some of the reasons why you should patronize Senieer as your preferred high shear mixer supplier:

• • • Vast Experience

Experience in the industry plays a crucial role in choosing a supplier for any product you want to buy. Senieer has been in the business of supplying quality pharmaceutical products in China for over 30 years.
With high-skilled and experienced personnel, Senieer has brought revolution to the pharmaceutical equipment manufacturing and supplying in China by offering expertise advice from lab production processes and sales of quality replaceable parts.

• • • Incorporation of Innovative Technology

Senieer is always at the forefront of introducing innovative solution to the pharmaceutical equipment manufacturing industry.
Senieer incorporates innovative solution for clean room system which includes clean room panel, clean room window, clean room door, etc. With that, you can rest assured that your equipment will function at the topmost level with you having nothing to worry about.
Also, Senieer has special kinds of dust-free solid dosage forms granulation lines for processes that require mind-blowing innovation technology for special applications.

• • • Customized Designs

Sometimes, some process require that you sketch a diagram of the equipment you need as the purposes are highly specific. At Senieer, we help you to actualize your equipment requirements by fabricating machines that suit your needs.
It takes only those who understand the process and know details to develop products that can do more than just the sum of individual components, and only a very few can match the level of skills and knowledge of Senieer in designing and fabricating customized equipment.

• • • Strong Partnership with Top Brands

One of the competitive advantage of Senieer is the strong business alliances that we have formed with top brands across the world.
At Senieer, we partner with first-class brands such as Siemens, Festo, ABB, Sefar, Schlick, Spirax Sarco, and many more to provide our customers with quality replaceable spare parts for your use.

Seamless Documentation Process

Having to undergo a rigorous process can be tasking and frustrating. As such, Senieer ensures that all documents related to the equipment guarantee easier training, operation and maintenance of the equipment throughout our equipment’s life term for an exigent industry like the pharmaceutical market.
We offer a complete set cGMP documents including Qualifications (DQ,IQ, OQ, ) , FAT, SAT, USER manual documentation. We perform the qualification executions as customer request.

• • • Compliance with International Standard

Senieer business sections operate under the strict International Quality Standard of operation. Our control regulation certificate called the “International Quality Certifications” is ISO9001in case you want to check for confirmation.

• • • Outstanding Customer Support

At Senieer, we understand that our customers are the reasons for our existence. Thus, we prioritize giving you quality customer service. We ensure that all your requests are handled with top professionalism. Our sales representatives are courteous and pay full attention to the unique needs of our customers irrespective of the size of their request.
If you desire bringing pharmaceutical productivity to a new level with 4.0 industry solution from pharmaceutical company, Senieer is the most capable hand you can trust.
We are more than pharmaceutical equipment supplier; we see ourselves more as partners with the commitment to achieve success with our clients.

• Aftersales Service

It is really heart-breaking to be left stranded after spending your hard-earned money on expensive equipment only for the product supplier to turn a deaf ear to your request when you need them the most.
At Senieer, we offer all our customers full aftersales support. If you need safe hands to handle all the challenges you experience after purchasing your pharmaceutical equipment, you are in the right place with Senieer.

Chapter 8: Cost and Shipping High Shear Mixer from China

The price of our Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s varies based on the type and several other factors, such as process requirements and specifications.
While Senieer might not be the cheapest supplier of high shear mixers in China, however, you can be sure that nobody offers you the better value for money than us.
If you are interested in making inquiries about the price of all our products, you can contact us, and please send your User Requirement Specification (URS), we will duly feedback to you.
If you are shipping your Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s from countries like Canada, the United States, South Korea, Thailand, Germany, Columbia, Egypt, Indonesia, Malaysia, Pakistan, Bangladesh, Turkey, Vietnam, etc. You can be sure that all our shipping processes will be taken care of expertly without you having to undergo any form of stress.
Basically, we ship Senieer products are shipped via the sea and railway lines. The rail is used in countries that share close proximity with China while sea freight is used for our customers ordering our products from long.
You can check here to see all the processes involved in shipping high shear mixer and other machinery from china via sea freight.     

Chapter 9: Frequently Asked Questions on Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator

How do Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s Work?

Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator s work by the forceful movement of two parts in opposite directions within the same plane to create a shear force. In a high shear mixer, the rotor circulates at high speed to propel materials outwardly directly to a stationary stator that carries out the actual shearing.
The technique used in a high shear mixer is such that the varying rotor speed allows the mixing equipment to gain shear energy that will be used in homogenizing solid or gas into a liquid which cannot be achieved without the help of a high shear mixer, this later forms granule.
High shear mixers works for dispersion, homogenization, particle size reduction and dispersion.

How does a Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator compare to a high pressure homogenizer?

High pressure homogenizer engages huge amount of energy to derive pressure needed to homogenize while high shear mixers make use of the actions of rotors and stators to derive particle size reduction.

Where can I use a Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator ?

A high shear mixer is both used in the laboratory for the manufacturer of pharmaceutical products such as drugs and capsules.

What is the laboratory models of high shear mixers?

It involves the use of laboratory high shear as a practical way to test technology in need of liquid processing on different applications. It is a fast and convenient way for the R&D department to assess the formulation and processing strategies before embarking on scaled production.

How much does a high shear granulation cost?

The money you will spend on a standard and quality Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator is dependent on what you need it for and the processing application. Irrespective of the amount spent is procuring a Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator , you can relax because you are bound enjoy a high return on investment. It will help you save time by shortening the production time. Also, it will improve your overall productivity, and help you save more on energy consumption and maintenance charges. If you are ready to purchase your high shear mixers and other pharmaceutical equipment, kindly get in touch with us and we will be glad to take your orders.

Conclusion

Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator is a very useful equipment for both laboratory and industrial uses. Although there are probably hundreds of high shear mixer manufacturers and suppliers in China. However, you have been able to see for yourself that none can match the quality of products and services of Senieer Rapid Mixer Granulator (RMG) or High Shear Mixer Granulator .
If you are looking for high shear mixer for sale in China and you want it shipped directly to use, feel free to get a free quick quotation from us right now.

Also, if you need any help on how to buy and get your high shear shipped to your doorstep, kindly contact Senieer now, and we will be glad to respond to you instantly.